Intermediates of Amlodipine

Amlodipine Besylate is a long-acting calcium channel blocker dihydropyridine (DHP) class drug used as an antihypertensive and in the treatment of angina pectoris. Like other calcium channel blockers Amlodipine besylate act by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance and hence reducing blood pressure; in angina and it also increases blood flow to the heart muscle. Amlodipine is also used to relieve chronic stable angina (chest pain) or vasospastic angina (Prinzmetal's or variant angina). This medicine is also used to lower the risk of hospitalization for angina and heart surgery (eg, coronary revascularization) in patients with recently documented coronary artery disease (CAD) by angiography and without certain heart problems (eg, heart failure or an ejection fraction less than 40%). Amlodipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. This relaxes the blood vessels and lowers blood pressure, and increases the supply of blood and oxygen to the heart while reducing its workload. This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

● Solution ● Suspension ● Tablet

What special precautions should I follow?

Before taking amlodipine,

● tell your doctor and pharmacist if you are allergic to amlodipine, any other medications, or any ingredients in amlodipine tablets or suspension. Ask your pharmacist for a list of the ingredients. ● tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: certain medications for seizures such as carbamazepine (Carbatrol, Equetro, Tegretol), phenytoin (Dilantin, Phenytek), and phenobarbital; clarithromycin (Biaxin, in Prevpac); cyclosporine (Gengraf, Neoral, Sandimmune); efavirenz (Sustiva); indinavir (Crixivan); itraconazole (Onmel, Sporanox); ketoconazole (Nizoral); lovastatin (Altoprev, in Advisor); nefazodone; nelfinavir (Viracept); nevirapine (Viramune); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, in Rifamate), ritonavir (Norvir, in Kaletra), simvastatin (Zocor, in Simcor, in Vytorin), and tacrolimus (Astragraf SL, Prograf). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. ● tell your doctor if you have or have ever had heart failure or heart or liver disease. ● tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking amlodipine, call your doctor.