DBA providing in Gujarat – Given the shifting outlook of Chinese manufacturing units, pharmaceutical intermediates businesses are among the most active industries in India today. Considering the needs of the Indian API business, which is heavily reliant on Chinese suppliers, this unit might be developed to meet those needs.
pharmaceutical firms in India
To begin, we will produce 2, 7-Dichloro-alpha-[(dibutylamino)methyl]-9H-fluorene-4-methanol
(DBA) is an anti-malarial medication intermediate named Lumefantrine.
DBA providing in Gujarat
1) DBA:
2-(2, 7-DICHLORO-9H-FLUORENYL-4-YL)OXIRANE (Oxirane) is reacted with Di-nbutyl amine in presence of a catalyst & n-Butanol as reaction medium. The solids formed in the reaction are filtered & dried under vacuum to get the product.
Type of reaction: Epoxide opening with secondary amine.
Chemical reactions :
2-(2,7-Dichloro-9H- Fluorenyl-4-yl) Oxirane Mol wt: 277.15
Di-n-butylamine Mol wt: 129
DBA Mol wt : 406.39
DBA providing in Gujarat
2) Tert-Butyl [(1S, 2R)-1-benzyl-2-hydroxy-3-(isobutyl amino) propyl]carbamate:
(2S,3S)-1,2-Epoxy-3-(Boc-amino)-4-phenylbutane (epoxide) is reacted with iso-butyl amine to get the product.
The product is isolated in presence of Toluene+Methanol.
Type of reaction: Epoxide opening with primary amine.
Chemical reaction:
(2S,3S)-1-2-epoxy-3-(boc-amino)-4-phenylbutane Mol wt: 263-34
Isobutyl amine Mol wt: 73
Tert-Butyl-[(1S,2R)-1-benzyl-2-hydroxy-3-(isobutylamino)propyl] carbamate Mol Wt: 336.47
DBA providing in Gujarat
3) 4-(2-Aminoethyl) phenol:
L-Tyrosine is heated in presence of a catalyst using N-methyl pyrrolidone/Diphenyl ether as reaction medium. After the completion of reaction the reaction medium is distilled out under vacuum. Toluene+Methanol is added to concentrated mass to get the product, which is filtered & dried.
Type of reaction: Decarboxylation.
Chemical reaction:
L-Tyrosine Mol wt: 181
4-(2-Aminoethyl)phenol Mol wt: 137
DBA providing in Gujarat
4) Methyl 2-(1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetate:
7-Ethyl tryptophol(7-ETP) is reacted with Methyl -3-oxo pentanaote in presence of a catalyst & using MDC as reaction
medium. Once the reaction is over the catalyst is filtered (recycle in next batch) & MDC is distilled out.
Methanol is added to isolate the product. Solids are filtered & dried to get the product.
Type of reaction: Six membered ring formation.
Chemical reaction:
7-Ethyl tryptophol Mol wt: 189.25
Methyl-3-pentanoate Mol wt: 130
Methyl-291,8-diethyl-1,3,4,9-tetrahydropyrano[3,4]-indol-1-yl acetate Mol wt: 301.35
DBA providing in Gujarat
5) Tetra methyl-1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate:
1,4,7,10-tetrazacyclododecane (cyclen) is reacted with Methyl bromo acetate in presence of a catalyst,
Potassium carbonate & using Acetonitrile as reaction medium. After the completion of reaction, salt
formed & excess potassium carbonate is filtered. The filtrate is distilled to recover Acetonitrile & get
the product.
Type of reaction: N-alkylation reaction
Chemical reaction:
Cyclen Mol wt: 172
Methyl bromoacetate Mol wt: 153
Dota ester Mol wt: 460
DBA providing in Gujarat
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