Description
Methyl 3-aminocrotonate undergoes waste-free solid-state cascade reaction with crystalline ninhydrin
Methyl 3-aminocrotonate is an intermediate in the synthesis of pyridinedicarboxylic acid. It is a white powder with a melting point of 160-165°C and a boiling point of 263°C. Methyl 3-aminocrotonate is soluble in water, alcohols, ethers, chloroform, and benzene. It has been detected by its UV absorption at 227 nm. The detection sensitivity for this compound was found to be 0.1 ppm. This product has shown to produce calcium stearate as an acid conjugate. Methyl 3-aminocrotonate is a molecule that contains a hydrogen bond between the hydroxyl group and the amine group on C3, which are both in close proximity to the carbonyl group on C2. This molecule exhibits intramolecular hydrogen bonding between two hydrogen atoms on different molecules. The IR spectrum for methyl 3-aminoc
Application
Methyl 3-aminocrotonate (Methyl 3-amino-2-butenoate) was used to synthesize 4-aryl-1,4-dihydropyridines possessing potential calcium channel blocking activity
Abstract
The present invention relates to a process for the preparation of methyl 3-aminocrotonate and is characterized in that it comprises the reaction of methyl acetoacetate with ammonia in the presence of water and at a temperature between 35 and 70 degree (s) C. This product constitutes an important raw material for the synthesis of drugs.
